Our Products

Rotary Evaporator

Laboratory equipment

Jacketed Reactor

Contact Us

We Cherish All Interactions

RNA oligonucleotide synthesis - ATDBio

RNA oligonucleotide synthesis - ATDBio

The synthesis of oligoribonucleotides using 2′-TBS phosphoramidite monomers follows a similar synthesis cycle to that of standard solid-phase DNA synthesis. The differences are: phosphoramidite coupling times are longer in RNA synthesis (up to 6 min) to allow for the steric bulk of the TBS group;

Automated Library Synthesis - FLEX ISYNTH from CHEMSPEED

Automated Library Synthesis - FLEX ISYNTH from CHEMSPEED

Reaction preparation, in conjunction with our unique overhead gravimetric dispensing of solids and liquids or solid-phase and liquid-phase synthesis Work-up by, e.g. extraction, evaporation, filtration, crystallization, integrated analysis by e.g. HPLC

Solid-Phase Supports for Oligo Synthesis

Solid-Phase Supports for Oligo Synthesis

May 01, 2012 · For a given reactor column volume, increasing solid-support nucleoside loading, dimensional stability during synthesis, and synthesis efficiency can significantly enhance synthesis .

26.10: The Merrifield Solid-Phase Technique - Chemistry .

26.10: The Merrifield Solid-Phase Technique - Chemistry .

The solid‑phase used in this method is a polymer support. You will not be examined on the details of the Merrifield solid‑phase method; however, you should be prepared to write a couple of paragraphs describing this important process. For his work on the synthesis of peptides, Bruce Merrifield was awarded the 1984 Nobel Prize in chemistry.

Solid Phase Synthesis - Combinatorial Chemistry

Solid Phase Synthesis - Combinatorial Chemistry

Mar 10, 2020 · Combinatorial Synthesis on Solid-Phase Since Merrifield pioneered solid phase synthesis back in 1963, work, which earns him a Nobel Prize, the subject, has changed radically. Merrifields Solid Phase synthesis concept, first developed for biopolymer, has spread in every field where organic synthesis is involved.

Designing a Solid Phase Peptide Synthesis Reactor Facility

Designing a Solid Phase Peptide Synthesis Reactor Facility

Dryer as a chemical synthesis reactor • This project has delivered a successful novel approach for commercial scale manufacture of the product in a safe, fully automated multiproduct facility . . Designing a Solid Phase Peptide Synthesis Reactor Facility Author: temp

Peptide Synthesis Vessels, Solid Phase, Chemglass | VWR

Peptide Synthesis Vessels, Solid Phase, Chemglass | VWR

Solid phase peptide synthesis vessel with a medium or coarse porosity fritted glass resin support.These cylindrical, heavy-walled reaction vessels are fabricated from borosilicate glass to accommodate immersion wells. Open-mouthed models facilitate the introduction and removal of materials and allow for easy cleaning. Wall thickness is uniform.

Solid–Gas Phase Synthesis of Coordination Networks by .

Solid–Gas Phase Synthesis of Coordination Networks by .

Jul 15, 2019 · In comparison, gas‐phase network synthesis remains largely unexplored. Herein, two new two‐dimensional coordination networks are obtained from the solid–gas phase reaction between ZnX 2 (X=I, Br) and the redox‐active 2,5,8‐tri(4‐pyridyl)1,3‐diazaphenalene (HTPDAP) ligand.

Solid-phase synthesis of molecularly imprinted polymer .

Solid-phase synthesis of molecularly imprinted polymer .

Preparation of the column reactor. The solid-phase synthesis approach is represented in Fig. 2. GBs were first activated by boiling in NaOH to introduce –OH groups 20,21.

DNA Oligonucleotide Synthesis | Sigma-Aldrich

DNA Oligonucleotide Synthesis | Sigma-Aldrich

Summary of solid-phase oligonucleotide synthesis cycle. In step 1, Detritylation, the 5'-DMT protecting group is removed from the first, solid-support-linked nucleoside. In step 2, Coupling, the free 5'-OH of the first, solid-support-linked nucleoside attacks the phosphorus of the incoming second nucleoside, displacing its diisopropylamino group.

Peptide Synthesis Glassware and Reactors

Peptide Synthesis Glassware and Reactors

Solid-phase peptide synthesis reactor. Kamysz vessel for solid-phase peptide synthesis. User definied vessels. Polypropylene vessels. Solid-phase peptide synthesis vessel, side thread with ground glass joint. up to 5x faster peptide synthesis for more information click. HOT Kamush Skiller.

Solid‐Phase Total Synthesis of Yaku'amide B Enabled by .

Solid‐Phase Total Synthesis of Yaku'amide B Enabled by .

Jan 13, 2020 · We report a solid‐phase strategy for total synthesis of the peptidic natural product yaku'amide B (1 ), which exhibits antiproliferative activity against various cancer cells.Its linear tridecapeptide sequence bears four β,β‐dialkylated α,β‐dehydroamino acid residues and is capped with an N‐terminal acyl group (NTA) and a C‐terminal amine (CTA).

Merrifield MicroTube(TM) reactors for solid phase synthesis

Merrifield MicroTube(TM) reactors for solid phase synthesis

Several reactions performed on Merrifield MicroTube(TM) reactors demonstrated that they are excellent supports for solid phase synthesis. As a result of the ease with which radiofrequency memory tags can be associated with and separated from the supports, these MicroTube(TM) reactors can facilitate the synthesis of combinatorial libraries.

Basic Peptides synthesis introduction - LifeTein®

Basic Peptides synthesis introduction - LifeTein®

Solid phase synthesis consists of assembling amino acids from the C-terminal to the N-terminal. SPPS allows efficient removal of excess reagents and soluble byproducts after each reaction cycle because the peptide remains anchored to an insoluble solid resin support. .

WO1998034633A1 - Reactor and method for solid phase .

WO1998034633A1 - Reactor and method for solid phase .

A solid phase peptide synthesis reactor system (1) and method of operating the reactor are provided. The reactor system (1) includes a basket (17) rotatable about an axis within a housing (7) and a sump/receiver (5) which delivers fluid to, and collects fluid from, the housing (7). The basket (17) has a perforate side (23) wall against which a resin cake (R) for the peptide synthesis is formed.

Automated Library Synthesis - FLEX ISYNTH from CHEMSPEED

Automated Library Synthesis - FLEX ISYNTH from CHEMSPEED

Reaction preparation, in conjunction with our unique overhead gravimetric dispensing of solids and liquids or solid-phase and liquid-phase synthesis Work-up by, e.g. extraction, evaporation, filtration, crystallization, integrated analysis by e.g. HPLC

Solid Phase Reaction - an overview | ScienceDirect Topics

Solid Phase Reaction - an overview | ScienceDirect Topics

Solid-phase reaction. In biological systems, reactions are sometimes mediated by catalysts in solid form (e.g., clumps, flocs, and films of cells) and by immobilised enzyme and cell particles. When cells or enzymes are clumped together into a solid particle, substrates must be transported into the solid before reaction can take place. Mass .

Solid-phase synthesis of Eptifibatide in a multifunctional .

Solid-phase synthesis of Eptifibatide in a multifunctional .

SHENG Zecui1, ZHOU Cheng1, ZHANG Lingzhi3, ZHU Liangliang1, JIANG Bo1, CHEN Yingwen1, ZHU Shemin2, SHEN Shubao1*. Solid-phase synthesis of Eptifibatide in a multifunctional reactor[J]. Chinese Journal of Applied Chemistry,2012, 29(03): 275-279. URL:

Solid Phase Synthesis - an overview | ScienceDirect Topics

Solid Phase Synthesis - an overview | ScienceDirect Topics

In particular, aqueous-phase modification of ONs by Sonogashira reaction has remained elusive, and hence, on-column Sonogashira reaction was used in the following examples. In one of the first examples, Khan and Grinstaff used Pd-catalyzed Sonogashira reaction during automated solid-phase synthesis to modify ONs.

(PDF) Methanol Synthesis Model and Reactor Design

(PDF) Methanol Synthesis Model and Reactor Design

The synthesis of methanol from CO and H2 was executed in a gas-solid-solid trickle flow reactor. The reactor consisted of three tubular reactor sections with cooling sections in between.

Real-time monitoring of solid-phase peptide synthesis .

Real-time monitoring of solid-phase peptide synthesis .

Solid-phase peptide synthesis (SPPS) is carried out using different types of automated peptide synthesis instruments including batch and continuous-flow (CF) reactors. 1–4 CF-SPPS benefits from increased coupling efficiencies, as a high flux of activated amino acid increases the relative local excess of reagents when compared to batch processes (). 5–7 In a CF system, the activated amino .

Peptide synthesis - Wikipedia

Peptide synthesis - Wikipedia

Solid-phase synthesis. The established method for the production of synthetic peptides in the lab is known as solid-phase peptide synthesis (SPPS). Pioneered by Robert Bruce Merrifield, SPPS allows the rapid assembly of a peptide chain through successive reactions of amino acid derivatives on an insoluble porous support.. The solid support consists of small, polymeric resin beads .

Solid Phase Synthesis | Protocol

Solid Phase Synthesis | Protocol

Solid phase synthesis is a method in which the product is synthesized while bound to an insoluble material. Solid phase synthesis is often used to produce biological oligomers and polymers such as peptides, nucleic acids, and oligosaccharides. These molecules are composed of chains of smaller molecular subunits, called monomers.

Solution Phase Synthesis - Combinatorial Chemistry

Solution Phase Synthesis - Combinatorial Chemistry

Mar 10, 2020 · Despite the focus on the use of solid-phase techniques for the synthesis of combinatorial libraries, there have been few examples where libraries have successfully been made and screened in solution. The benefit of preparing libraries on resin beads has been explained as offering advantages in handling, especially where a need to separate .

Solid-state synthesis, magnetic and structural properties .

Solid-state synthesis, magnetic and structural properties .

Here we first report results of the start of the solid-state reaction at the Rh/Fe(001) interface and the structural and magnetic phase transformations in 52Rh/48Fe(001), 45Rh/55Fe(001), 68Rh/32Fe .

Buchiglas - Solid Phase Peptide Synthesis Equipment (SPPS)

Buchiglas - Solid Phase Peptide Synthesis Equipment (SPPS)

Büchi Glas Uster - Solid Phase Synthesis Equipment Büchi AG in Uster Switzerland is a leading manufacturer of pilot-plant and pressure reactors for the chemical and pharmaceutical industry. The plants and reactors made from glass and metal are exported to over 40 countries worldwide.

Continuous Flow-based Solid-phase Peptide Synthesiser

Continuous Flow-based Solid-phase Peptide Synthesiser

of our current platform in the synthesis of ACP, a peptide sequence known for its difficult solid-phase synthesis due to collapsing and aggregation of the peptide chain during the process. The synthesis starts with packing the flow reactor with Rink amide resin preloaded with the C-terminal Gly residue.

(PDF) Methanol Synthesis Model and Reactor Design

(PDF) Methanol Synthesis Model and Reactor Design

The synthesis of methanol from CO and H2 was executed in a gas-solid-solid trickle flow reactor. The reactor consisted of three tubular reactor sections with cooling sections in between.

Solid-phase synthesis - Wikipedia

Solid-phase synthesis - Wikipedia

Solid-phase synthesis - Wikipedia

Solid‐Phase Total Synthesis of Yaku'amide B Enabled by .

Solid‐Phase Total Synthesis of Yaku'amide B Enabled by .

Jan 13, 2020 · We report a solid‐phase strategy for total synthesis of the peptidic natural product yaku'amide B (1 ), which exhibits antiproliferative activity against various cancer cells.Its linear tridecapeptide sequence bears four β,β‐dialkylated α,β‐dehydroamino acid residues and is capped with an N‐terminal acyl group (NTA) and a C‐terminal amine (CTA).