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Keys to successful single-use bioreactor scale up – from .

Keys to successful single-use bioreactor scale up – from .

In the poster, authors used BioBLU Single-Use Vessels of different sizes (maximum working volumes of 0.25 L, 3.75 L, and 40 L) that are of geometrically similar stirred-tank design to scale up a mAb CHO process from small to pilot scale production. Bioreactor Scale Up Considerations

Bioreactor | Subnautica: Below Zero | Fandom

Bioreactor | Subnautica: Below Zero | Fandom

The Bioreactor is constructed with the Habitat Builder and composts organic matter into Energy. It has a 4×4 inventory grid to place organic items into, and items placed inside it cannot be removed once placed. It can break down any organic matter into reliable energy for Seabases. The Bioreactor produces 1 energy every 1.2 seconds (50 per minute) with a maximum capacity of 500 units per .

Utah State University DigitalCommons@USU

Utah State University [email protected]

Utah State University [email protected] All Graduate Theses and Dissertations Graduate Studies 5-2011 Comparative Studies on Scale-Up Methods of Single-Use

Fermentation & Bioreactors | Sartorius

Fermentation & Bioreactors | Sartorius

Discover the broadest selection of bioreactors & fermenters in the industry. Scalable from 8 mL up to 2,000 L, single-use or made from stainless steel!

HyPerforma Single-Use Mixers | Thermo Fisher Scientific - US

HyPerforma Single-Use Mixers | Thermo Fisher Scientific - US

The Thermo Scientific HyPerforma Single-Use Mixer (S.U.M.) has been designed using a proven engineered mixer platform design and offers a more ergonomic and efficient user experience for upstream and downstream mixing applications.The complete line of HyPerforma S.U.M.s includes 50, 100, 200, 500, 1,000 and 2,000 L sizes that helps ensure consistent scalability while providing a .

Mobius® Single-use Bioreactors | Single-use Manufacturing .

Mobius® Single-use Bioreactors | Single-use Manufacturing .

Scalable, Simple, Smart and Reliable. Mobius® Single-Use Bioreactors are a scalable portfolio of stirred tank bioreactors that provide flexibility by configuring software, hardware, and single-use assemblies for use in fed-batch and perfusion applications.. The Mobius® Bioreactor family includes the bench scale (3 L), pilot-scale (50 L and 200 L), and clinical scale (1000 L and 2000 L .

5 Liter Bioreactor Assembly (Cell Culture) - Broadley-James

5 Liter Bioreactor Assembly (Cell Culture) - Broadley-James

5 Liter Bioreactor Assembly (Cell Culture) The BioNet® Bioreactor is the latest in autoclavable benchtop glass vessels. Available in a range of sizes: 3, 5, 7, 15 and 20 liters total volume. All metal components are manufactured from 316L stainless steel with electropolish. Integral scaling, improved component designs and extensive product .

Simplify Upstream Process Development and Scale-Up: Single .

Simplify Upstream Process Development and Scale-Up: Single .

For example, cells first are grown in a 2-L shake flask or glass bioreactor, then in a 10-L glass bioreactor. When conditions have been optimized at small scale, a process then moves to a 50-L bioreactor before further scaling up to 250-L and 1,000-L bioreactors, with additional optimization as .

BioBLU ® c Single-Use Vessels - Eppendorf International

BioBLU ® c Single-Use Vessels - Eppendorf International

BioBLU ® 0.3c Single-Use Vessel, cell culture, open pipe, 1 pitched-blade impeller, no pH, sterile, 4 pieces Catalog No. 1386100000

Used Bioreactors | Buy & Sell | EquipNet

Used Bioreactors | Buy & Sell | EquipNet

EquipNet is the world's leading provider of used bioreactors and various other preowned equipment. Our exclusive contracts with our clients yield a wide range of used bioreactors from a number of respected OEMs, including Wave Biotech, Thermo Scientific, B. Braun Biotech, New Brunswick Scientific, Precision Stainless, Xcellerex, Lee Industries, and many more.

PubMed - National Center for Biotechnology Information

PubMed - National Center for Biotechnology Information

We evaluated the sparger kLa and kLaCO2 (CO 2 volumetric mass transfer coefficient) from a range of bioreactor scales (3-2,000 L) with different spargers. Results demonstrated that kLa for oxygen is not an issue when scaling from small-scale to large-scale bioreactors at the same gas .

HyPerforma Single-Use Mixers | Thermo Fisher Scientific - US

HyPerforma Single-Use Mixers | Thermo Fisher Scientific - US

The Thermo Scientific HyPerforma Single-Use Mixer (S.U.M.) has been designed using a proven engineered mixer platform design and offers a more ergonomic and efficient user experience for upstream and downstream mixing applications.The complete line of HyPerforma S.U.M.s includes 50, 100, 200, 500, 1,000 and 2,000 L .

Compact Bioreactors - Solida Biotech

Compact Bioreactors - Solida Biotech

Parallel controller and Software capabilites up to 12 bioreactors systems to accelerate the development of your bioprocesses. Lab efficiency. Small footprint Bioreactor occupying a truly reduced surface of 280x400mm WxD or 100×400 inches (US) to .

Fermenter - Bioreactor | LAMBDA

Fermenter - Bioreactor | LAMBDA

MINIFOR laboratory fermentor and bioreactor. The LAMBDA MINIFOR bench-top autoclavable laboratory fermenter and bioreactor was developed as a result of the need to construct a small laboratory fermentor for working volume ranges from 35 ml to over 6 liters.. Based on long personal practical experience in fermentation and cell culture, a high quality fermentor-bioreactor which is .

Bioreactor

Bioreactor

Jun 30, 2020 · Like and subscribe. How to Grow Roses From Cuttings Fast and Easy | Rooting Rose Cuttings with a 2 Liter Soda Bottle - Duration: 28:23. Mike Kincaid Recommended for you

Stainless Steel Bioreactors & Fermenters | Sartorius

Stainless Steel Bioreactors & Fermenters | Sartorius

The Sartorius portfolio of stainless steel fermenters and bioreactors includes standard products from 5 L to 200 L and customized engineering solutions up to 2,000 L. Our long-standing process knowledge combined with the unrivaled quality of our fermenter .

Micro-Scale Bioreactors in Fed-batch Microbial Screening .

Micro-Scale Bioreactors in Fed-batch Microbial Screening .

The DO transfer data (Figure 2) shows that the micro bioreactor can achieve a maximum KLa of approximately 380 h-1, which is comparable to the oxygen transfer rate generated in 100 mL to 1L benchtop (1) and 14,000-20,000L pilot-scale bioreactors (2). The maximum KLa achieved indicates that the micro bioreactor can provide sufficient oxygen to .

What Does Solazyme's 500,000-Liter Fermenter Really Mean .

What Does Solazyme's 500,000-Liter Fermenter Really Mean .

What Does Solazyme's 500,000-Liter Fermenter Really Mean? While reaching 500,000 L is a big development, there are still plenty of things that can go wrong.

Development of a Scale-Down Model for rAAV Viral Vector .

Development of a Scale-Down Model for rAAV Viral Vector .

same amount of bioreactors in one week whereas it takes two weeks in 2 L glass bioreactors." Using the DASbox system also helped reduce costs, by facilitating the performance of studies in small-scale bioreactors. A 1x105 1x106 02 448 72 V i a b l e a c e l l s e / m L Time (h) 300 rpm 400 rpm 375 rpm 2 L bioreactor, 180 rpm (n=6) B 2 14 16 .

iCELLis® Bioreactor - Cell Culture | Pall Shop

iCELLis® Bioreactor - Cell Culture | Pall Shop

The iCELLis bioreactor systems are available in two formats: The iCELLis Nano system for feasibility studies and small-scale production (up to 4 m 2) The iCELLis 500+ system for industrial scale manufacturing (up to 500 m 2)

(PDF) Bioreactor Design - ResearchGate

(PDF) Bioreactor Design - ResearchGate

6.2 BIOREACTORS BACKGROUND. The main objective of a properly designed bioreactor is to pr ovide a controlled environment to. . Small openings must be made lea k-proof with an O-ring, .

The Flexibility of Small-Scale Single-Use Bioreactor .

The Flexibility of Small-Scale Single-Use Bioreactor .

The small-scale bioreactor process examined was scaled up to 2000-L scale, and it was found that with respect to cell-culture performance, metabolite profiles, product titer, and product quality, both the single-use bioreactors and the 5-L glass vessels provided good small-scale models of the large-scale model.

Cell Culture Scale-Up in Stirred-Tank Single-Use Bioreactors

Cell Culture Scale-Up in Stirred-Tank Single-Use Bioreactors

L a) describes the efficiency with which oxygen can be delivered to a bioreactor culture for a given set of parameter conditions. For proper cell culture scale-up, it is important to select equipment of different sizes with similar k L a capabilities so that small-scale success can be .

Stainless Steel Bioreactors - Applikon Biotechnology

Stainless Steel Bioreactors - Applikon Biotechnology

The microbial Sterilizable-In-Place bioreactor systems come in a total volume of 15 L, 20 L, 30 L, 40 L, 70 L and 140 L. The cell culture Sterilizable-In-Place bioreactor systems come in a total volume of 15 L, 20 L, 30 L, 60 L and 130 L. The main difference between these two lines is the aspect ratio of the bioreactors.

Fermenters and Bioreactors | New and Used Lab Fermenters .

Fermenters and Bioreactors | New and Used Lab Fermenters .

Industrial-scale fermenters, or bioreactors, are used for propagation of organisms for protein synthesis, or production of chemicals or drugs from chemical precursors. The scale, adaptability, and suitability are important considerations, as well as the requirements involved in breakdown and maintenance.

CerCell - Configurable batch Single-Use-Bioreactor

CerCell - Configurable batch Single-Use-Bioreactor

Customized Bioreactor. Let's design your preferred Single-Use-Bioreactor (SUB). No standard SUB will satisfy your needs anyway! Out of 5.000 different parts it should be possible to assemble a CerCell design specifically for you.

Mobius® 3L Single-use Bioreactor - Mobius Mixing Systems

Mobius® 3L Single-use Bioreactor - Mobius Mixing Systems

Eliminate the need to clean, autoclave and assemble your traditional glass bioreactors and save days of downtime with the Mobius® 3L Single-use Bioreactor. - Find MSDS or SDS, a COA, data sheets and more information.

4 Process Involved in Scale up Criteria | Microbial .

4 Process Involved in Scale up Criteria | Microbial .

Oxygen is only sparingly solube in cell culture medium (0.2 m mole O 2 I-1). Oxygen demand of a culture (10 6 cells per ml) ranges between 0.053 m mole O 2 l-1 h-1 and 0.59 m mole O 2 I-1 h-1 depending on the type of cell. Scale up of mammalian cell cultures are, therefore, bound by .

Cell Culture Scale-Up in Stirred-Tank Single-Use Bioreactors

Cell Culture Scale-Up in Stirred-Tank Single-Use Bioreactors

L a) describes the efficiency with which oxygen can be delivered to a bioreactor culture for a given set of parameter conditions. For proper cell culture scale-up, it is important to select equipment of different sizes with similar k L a capabilities so that small-scale success can be .

High quality glass autoclavalbe bioreactors and fermentors

High quality glass autoclavalbe bioreactors and fermentors

The stirred tank reactor (STR) is the most widely used bioreactor type. Glass autoclavable bioreactors and fermentors are available in jacketed and single wall versions in 2, 3, 5, 7, 15 and 20 liter total volume (20 liter only in single wall version).